Probiotics May Be Useful Against Colds, Flu-Like S
Probiotics May Be Useful Against Colds, Flu-Like Symptoms in Children
August 12, 2009 —
Probiotics may be
useful as prophylaxis against cold and influenza-like symptoms in
children,
according to the results of a double-blind, placebo-controlled study
reported
in the August issue of Pediatrics.
"Selected strains of
probiotics
have been tested for human health benefits in a variety of disease
conditions,
but much less is known regarding prophylactic benefits in healthy
populations," write Gregory J. Leyer, PhD, from Danisco in
The effects of probiotic
intake on
incidence and duration of cold and influenza-like symptoms during the
winter
season were evaluated in healthy children aged 3 to 5 years. Of 326
eligible
children, 104 were randomly assigned to receive placebo, 110 to Lactobacillus
acidophilus NCFM, and 112 to L acidophilus NCFM in
combination with Bifidobacterium
animalis subsp lactis Bi-07. Children were treated twice
daily for 6
months.
Compared with the placebo
group, the
groups receiving single and combination probiotics fared significantly
better
in several outcomes. Fever incidence was 53.0% lower with single
probiotics (P
= .0085) and 72.7% lower with combination probiotics (P = .0009);
coughing incidence 41.4% (P = .027) and 62.1% (P = .005)
lower;
and rhinorrhea incidence 28.2% (P = .68) and 58.8% (P
=.03)
lower, respectively.
Fever, coughing, and
rhinorrhea
duration were 32% lower with single strain vs placebo (P = .0023)
and
48% lower with the strain combination (P < .001). Antibiotic
use
incidence was 68.4% lower for single strain vs placebo (P =
.0002) and
84.2% lower for the strain combination (P < .0001). Days
absent from
group child care were also 31.8% lower for single strain vs placebo (P
=.002) and 27.7% lower for the strain combination (P < .001).
"Daily dietary probiotic
supplementation for 6 months was a safe effective way to reduce fever,
rhinorrhea, and cough incidence and duration and antibiotic prescription
incidence, as well as the number of missed school days attributable to
illness,
for children 3 to 5 years of age," the study authors write. "No
notable adverse events were attributed to study probiotic strains."
Limitations of this study
include
failure to evaluate mucosal colonization, underlying mechanisms, or the
effect
of probiotics in an acute response to signs of illness.
"Daily probiotic dietary
supplementation during the winter months was a safe effective way to
reduce
episodes of fever, rhinorrhea, and cough, the cumulative duration of
those
symptoms, the incidence of antibiotic prescriptions, and the number of
missed
school days attributable to illness," the study authors conclude. "L
acidophilus NCFM alone was effective. There was, however, a trend
for a
broader protective effect with the combination of L acidophilus
NCFM and
B lactis Bi-07."
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